First, the basic properties of butyric acid (or butyrate) and the state of the body
1, pKa = 4.82, hydrophilic, lipophilic, volatile.
2, in the stomach with non-dissociated butyric acid molecules, in the small intestine, large intestine with dissociated butyrate ions (in the form of ions, there is no bactericidal effect).
Second, the effect site, function, efficacy, mechanism of action of butyric acid (or butyrate)
Effect site: stomach, small intestine, large intestine (cecum, colon).
Function: energy source of colon cells; promote intestinal mucosal synthesis; ketone body synthesis; promote intestinal cell proliferation, differentiation and maturation.
Efficacy: reduce the pH in the stomach, increase the protein digestibility; promote the development of small intestinal cells and maintain the structural integrity of the small intestine; promote the health of the hindgut.
Mechanism of action: direct action of the stomach and large intestine; indirect action of the small intestine (gene regulation).
Third, sodium butyrate products - non-coated products from the role of ordinary acidifiers, lipid coated products with special small intestinal function control role
The first generation of products: purity of 90-95%, powdery (disadvantages: volatilization, agglomeration, odor).
The second generation product 1: palm oil hard fat, vegetable oil (hydrogenated saturated fat) coated particles, the concentration is 30% (disadvantages: low concentration, the body fat digestion function is good).
Second generation product 2: corn syrup or starch coated granules, concentration 90% (disadvantages: water-soluble coating, unable to reach the back end of the intestine).
The third generation of products: plant oil coated particles, the concentration is 70% (disadvantages: need the body fat digestion function is good).
　 Fourth, the key point of the quality of coated sodium butyrate product - the stomach can be wrapped, the small intestine dissolved in the
1. The ratio of release of different effect sites - should be avoided in the stomach, with a focus on release in the small intestine.
2, coating material - plant oil fatty acid composition, carbon chain length (young animals on long-chain, saturated fatty acid digestibility of low).
3. Concentration (particle size)--The weight of the coated granules of the coating material determines the release rate of sodium butyrate (the less the proportion of the coating material, the more easily the sodium butyrate dissolves).
5. Application of butyric acid (or sodium butyrate) products in livestock and poultry farming
1. The non-coated product exerts an effect in the stomach, lowers the pH in the stomach, increases the protein digestibility and cannot reach the small intestine and the large intestine, and has no effect on the structure and dysfunction of the small intestine caused by weaning, and has no effect on the growth performance.
2, vegetable oil coating products - the effect is unstable, may be related to the age of the animal, the product coated with lipids, the amount of additives.
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