The recrystallization method
Recrystallization is the most commonly used method for the preparation of cyclodextrin inclusion compounds in laboratories. Recrystallization method refers to the first amount of cyclodextrin dissolved in hot water, then add a certain percentage of volatile oil, stir well placed in the refrigerator after a period of time, and then suction filter, drying can be cyclodextrin inclusion The The factors affecting the recrystallization method are temperature and time, the ratio of cyclodextrin to volatile oil, and the ratio of feed ratio and temperature are the most important.
Ginding method
Grinding method refers to the room temperature, the first cyclodextrin dissolved in a certain amount of water, and then add volatile oil and stir evenly, after low temperature drying can get clathrate. If the use of manual grinding, due to laborious time, only for small batch. Now the use of mechanical grinding method to prepare Cyclodextrin Inclusion Compound, its advantages are fast, simple, more suitable for industrial production, and volatile oil utilization is also higher.
Freeze-drying method
The freeze-drying method refers to the addition of the volatile oil to a saturated aqueous solution of cyclodextrin, mixing it uniformly by stirring, and then removing the solvent by freeze-drying to obtain a powdery inclusion compound. For the evaporation of volatile, decomposition, discoloration of volatile oil commonly used freeze-drying method.
Ultrasonic method
Ultrasonic method refers to the volatile oil added to the cyclodextrin aqueous solution, mixed even after mixing without mixing, but the use of ultrasound to direct inclusion, and then the inclusion compound in the refrigerator, and then by filtration, washing, drying That is, clathrate. Ultrasonic method has the advantages of simple operation, high inclusion rate, easy to industrial production. The factors influencing the preparation of clathrate by ultrasonic method are temperature, material ratio, ultrasonic time and so on.
Amino Mercapto iodo cyclodextrin mainly including Mercapto Beta Alpha Gamma Cyclodextrin, Amino Beta Cyclodextrin, Iodo Beta Alpha Gamma Cyclodextrin.
Amino Beta Cyclodextrin mainly including mono-(6-amino-6-deoxy) beta cyclodextrin, Heptakis(6-amino-6-deoxy) beta cyclodextrin,mono amino beta cyclodextrin,heptakis(6-amino-6-deoxy)-beta-cyclodextrin,hexakis-(6-mercapto-6-deoxy)-alpha-cyclodextrin.
Mercapto Beta Alpha Gamma Cyclodextrin mainly including mono-(6-Mercapto-6-deoxy) beta Cyclodextrin, Heptakis-(6-Mercapto-6-deoxy) beta Cyclodextrin, Hexakis-(6-Mercapto-6-deoxy) alpha Cyclodextrin,mono-6-mercapto-6-deoxy beta cyclodextrin,mono mercapo beta cyclodextrin,heptakis mercapto beta cyclodextrin.
Iodo Beta Alpha Gamma Cyclodextrin mainly including Hexakis-(6-Iodo-6-Deoxy) alpha Cyclodextrin, Heptakis(6-iodo-6-deoxy)-beta-cyclodextrin, Octakis-(6-Iodo-6-Deoxy)-gamma-Cyclodextrin.
Iodine group is lively and active groups, it is easy to be replaced by other groups. Iodine generation of alpha, beta, gamma - cyclodextrin is an important intermediate of cyclodextrin derivatives synthesis
SaveAmino Cyclodextrin Mercapto Cyclodextrin iodo cyclodextrin
Amino Beta Cyclodextrin,Iodo Beta Alpha Gamma Cyclodextrin,Mercapto Beta Alpha Gamma Cyclodextrin
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